You should know that Glucagon-like peptide-1
*increases insulin secretion
*increases beta cells
**decreases food intake by increasing satiety.**
Gastric Bypass => Increases GLP1
Glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a gut hormone. The biologically active forms of GLP-1 are: GLP-1-(7-37) and GLP-1-(7-36)NH2. Those peptides results from selective cleavage of the proglucagon molecule.
GLP-1 possesses several physiological properties that make it (and its analogs) a subject of intensive investigation as a potential treatment of diabetes mellitus.. The known physiological functions of GLP-1 include:
- increases insulin secretion from the pancreas in a glucose-dependent manner.
- decreases glucagon secretion from the pancreas by engagement of a specific G-Protein coupled receptor.
- increases insuline-sensitivity in both alpha cells and beta cells
- increases beta cells mass and insulin gene expression, post-translational processing and incretion.
- inhibits acid secretion and gastric emptying in the stomach.
- decreases food intake by increasing satiety.
- promotes insulin sensitivity.
As a proof of the physiological role of GLP-1 in post-prandial insulin secretion, it has been shown that an oral dose of glucose triggers a much higher peak in plasmatic insulin concentration compared to an intravenous dose.