oral fructose-sorbitol provoked GI symptoms in 15 ED patients and one healthy control (P<0.05 ED vs control).
World J Gastroenterol. 2009 Nov 14;15(42):5295-9.
Fructose-sorbitol ingestion provokes gastrointestinal symptoms in patients with eating disorders.
Department of Obstetrics and Gastroenterology, Royal North Shore Hospital, University of Sydney, Sydney 2065, Australia.
AIM: To evaluate gastrointestinal (GI) symptoms and breath hydrogen responses to oral fructose-sorbitol (F-S) and glucose challenges in eating disorder (ED) patients.
METHODS: GI symptoms and hydrogen breath concentration were monitored in 26 female ED inpatients for 3 h, following ingestion of 50 g glucose on one day, and 25 g fructose/5 g sorbitol on the next day, after an overnight fast on each occasion. Responses to F-S were compared to those of 20 asymptomatic healthy females.
RESULTS: F-S provoked GI symptoms in 15 ED patients and one healthy control (P<0.05 ED vs control). Only one ED patient displayed symptom provocation to glucose (P<0.01 vs F-S response). A greater symptom response was observed in ED patients with a body mass index (BMI)<or=17.5 kg/m2 compared to those with a BMI>17.5 kg/m2 (P<0.01). There were no differences in psychological scores, prevalence of functional GI disorders or breath hydrogen responses between patients with and without an F-S response.
CONCLUSION: F-S, but not glucose, provokes GI symptoms in ED patients, predominantly those with low BMI. These findings are important in the dietary management of ED patients.
PMID: 19908337 [PubMed – indexed for MEDLINE]PMCID: PMC2776856Free PMC Article
Figure 1Hourly and total symptom scores in eating disorder patients following ingestion of 25 g fructose-5 g sorbitol (F-S) and 50 g glucose (aP < 0.05 vs glucose).World J Gastroenterol. 2009 November 14;15(42):5295-5299.Figure 2Total symptom scores (mean ± SE) in eating disorder patients following ingestion of 25 g fructose-5 g sorbitol, grouped according to body mass index (BMI).World J Gastroenterol. 2009 November 14;15(42):5295-5299.