Vitamin D=Increased Falls and Fractures
High-Dose Vitamin D Linked With Increased Risk of Falls, Fractures Among Older Women
ScienceDaily (May 12, 2010) — Women age 70 years or older who received a single annual high dose of vitamin D had a higher rate of falls and fractures compared to women who received placebo, according to a study in the May 12 issue of JAMA.
The results of studies investigating the effects of cholecalciferol (vitamin D) supplementation on falls and fractures have been inconsistent, with some meta-analyses indicating a reduced fracture risk, while others have concluded that vitamin D supplementation is ineffective, or may increase the risk of fracture. For individuals attempting to modify their risk of falls or fractures via vitamin D, adherence to daily supplementation is typically poor, according to background information in the article.
Kerrie M. Sanders, Ph.D., of the University of Melbourne, Geelong, Australia and colleagues conducted a study to examine whether high-dose cholecalciferol (500,000 IU) given orally once a year to older women would reduce falls and fractures. The vitamin D was given in a single, high-dose to address low adherence and to be a practical intervention easily translated to clinical practice. The trial included 2,256 community-dwelling women, ages 70 years or older, considered to be at high risk of fracture, who were recruited from June 2003 to June 2005 and were randomly assigned to receive 500,000 IU of cholecalciferol or placebo each autumn to winter for 3 to 5 years. The study concluded in 2008.