Guidelines for the diagnosis and treatment of Clostridium difficile

Med J Aust. 2011 Apr 4;194(7):353-8.
Australasian Society for Infectious Diseases guidelines for the diagnosis and treatment of Clostridium difficile infection.
Cheng AC, Ferguson JK, Richards MJ, Robson JM, Gilbert GL, McGregor A, Roberts S, Korman TM, Riley TV.
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Clostridium difficile is the most common cause of health care-associated and antibiotic-associated diarrhoea. These guidelines are intended to provide advice to clinicians on the clinical assessment, diagnosis and management of C. difficile infection (CDI). Hypervirulent strains of C. difficile, including PCR ribotype 027 strains recently identified in Australia, have been associated elsewhere with epidemic spread and high rates of severe disease and death. Diagnostic tests include stool culture, polymerase chain reaction-based assays, cell-culture cytotoxicity assays and enzyme immunoassay


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