Special Conjugated linoleic acid (CLA) **Isomers** Lead to Lowering Body Fat

Special Conjugated linoleic acid (CLA) **Isomers** Lead to Lowering Body Fat

CLA caused a clear reduction in **fat** mass (retroperitoneal and mesenteric), aand no other tissues were affected.

Conjugated linoleic acid (CLA) modulates body composition, especially by reducing adipose tissue. However, despite the increasing knowledge about CLA’s beneficial effects on obesity management, the mechanism of action is not yet fully understood.

Furthermore, in some human studies fat loss is accompanied by impairment in insulin sensitivity,
**especially when using the trans-10,cis-12 isomer.**

Mice were orally treated with a mixture of CLA isomers, cis-9,trans-11 and trans-10,cis-12 (50:50), for 35 days

Amplify’d from www.ncbi.nlm.nih.gov

Moderate doses of conjugated linoleic acid isomers mix contribute to lowering body fat content maintaining insulin sensitivity and a noninflammatory pattern in adipose tissue in mice.

Source

Laboratorio de Biología Molecular, Nutrición y Biotecnología, University of the Balearic Islands and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), E-07122, Palma de Mallorca, Spain.

Abstract

Conjugated linoleic acid (CLA) modulates body composition, especially by reducing adipose tissue. However, despite the increasing knowledge about CLA’s beneficial effects on obesity management, the mechanism of action is not yet fully understood. Furthermore, in some human studies fat loss is accompanied by impairment in insulin sensitivity, especially when using the trans-10,cis-12 isomer. The aim of this work was to study the effects of moderate doses of CLA on body fat deposition, cytokine profile and inflammatory markers in mice. Mice were orally treated with a mixture of CLA isomers, cis-9,trans-11 and trans-10,cis-12 (50:50), for 35 days with doses of CLA1 (0.15 g CLA/kg body weight) and CLA2 (0.5 g CLA/kg body weight). CLA had discrete effects on body weight but caused a clear reduction in fat mass (retroperitoneal and mesenteric as the most sensitive depots), although no other tissue weights were affected. Glucose and insulin were not altered by CLA treatment, and maintenance of glucose homeostasis was observed even under insulin overload.

The use of a mixture of both isomers, as well as moderate doses of CLA, is able to induce a reduction of fat gain without an impairment of adipose tissue function while preserving insulin sensitivity.

Read more at www.ncbi.nlm.nih.gov

 

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