Lipitor (atorvastatin) pretreatment protects against nerve injury

high-dose atorvastatin pretreatment can protect against sciatic nerve crush injury

Amplify’d from www.ncbi.nlm.nih.gov
Neurosurgery. 2010 Aug;67(2):376-88; discussion 388-9.

Neuroprotective effect of atorvastatin in an experimental model of nerve crush injury.

Source

Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan.

Abstract

BACKGROUND:

Statins have therapeutic benefits for the management of several disorders. A short-term course of a high-dose statin pretreatment has demonstrated neuroprotective effects against neurological diseases. However, the molecular basis underlying the neuroprotective action of statins remains unclear.

OBJECTIVE:

We investigated whether a short-term course of high-dose atorvastatin pretreatment has beneficial effects in protecting sciatic nerve from crush injury.

METHODS:

Atorvastatin (5 mg/kg) or saline was given orally to Sprague-Dawley rats for 7 days before injury. The rats were subjected to crush injury in the left sciatic nerve with a vessel clamp. Biochemical, functional, electrophysiological, and morphological alterations occurring during injury-induced degeneration/regeneration were examined.

RESULTS:

Atorvastatin improved injury-induced neurobehavioral/electrophysiological changes and axonal loss. Damage-associated alterations, including structural disruption, oxidative stress, inflammation, and apoptosis, were attenuated by atorvastatin. After injury, regeneration-associated genes, including growth-associated protein-43, myelin basic protein, ciliary neurotrophic factor, and collagen, were upregulated by atorvastatin. The suppression of extracellular signal-regulated kinase, AKT, signal transducer and activators of transcription-1, and necrosis factor-kappaB and the elevated activation of c-Jun N-terminal kinase, Smad2/3, and activating protein-1 were associated with the neuroprotective action of atorvastatin.

CONCLUSION:

These findings suggest that a short-term course of high-dose atorvastatin pretreatment can protect against sciatic nerve crush injury through modifying intracellular or extracellular environments, making it favorable for regeneration.

Read more at www.ncbi.nlm.nih.gov

 

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